Lab News

An article on the blockade of perchlorate-exposure-induced spermatogenic defects with vitamin C has been published in Environmental Science and Technology journal. This work was initiated at UNCG and completed at MU.  Beh Reh, a medical student, and Yashi Feng, a research specialist at Georgia State University, are student co-authors.
Congratulations, Sourav and the team of amazing co-authors!
‡,#Chakraborty, S.; #,*Reh, B.; ‡Anand, S.; **Feng, Y.;  Bhandari, R.K. (2025). Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka. Environmental Science and Technology. (in press) doi: 10.1021/acs.est.5c09514 #Equally contributing first authors.  

* Undergraduate student, ** Graduate student, ‡Scienitsts with Ph.D. 

A review manuscript on environmentally induced transgenerational liver disease has been published in the Epigenetics Reports journal. This is the first manuscript of Jaya and Anjana. Best of luck with your other upcoming manuscripts.
Congratulations, Dr. Chakraborty, Jayasree Nath, and Anjana Giri!
‡Chakraborty, S., **Nath, J., **Giri, A., Bhandari, R.K. (2025). Epigenetic basis for environmentally induced liver disease. Epigenetics Reports 3(1): 2586678..

Metabololic and transcriptomic analysis of the liver revealed disrupted proline and arginine metabolism in the liver due to ancestral BPA exposure. The manuscrpt describing this phenotype and mechanisms involved has been accepted for publication in the Environmental Toxicology and Chemistry- A Society of Environmental Toxicology journal.
Congratulations, Sourav and Co-authors!
**Chakraborty, S., Anand, S., Numan, M., Bhandari, R.K. (2025). Ancestral bisphenol A exposure led to nonalcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver. Environmental Toxicology and Chemistry. 44(4): 958-972. 

A manuscript from our core research project on susceptibility of current generation with a history of grandparental BPA exposure to endocrine disruption upon the second hit by PFOS has been accepted for publication in the Environmental Research journal. 

Congratulations, Sourav and Seraiah!
‡#Chakraborty, S., **#Coe, S.T., Anand, S., ‡Faheem, M., Wang, X., Bhandari, R.K. (2025). PFOS caused fertility defects and disrupted spermatogenic gene networks in the male medaka with a transgenerational history of ancestral BPA exposure. Environmental Research. 122056. # equal contribution.

A manuscript from our core research project on the methylation of medaka gametes has been accepted for publication in the Epigenetics journal. Congratulations, Dr. Xuegeng Wang!
Wang, X., Bhandari, R.K. (2024). Methylome profile of medaka eggs and sperm. Epigenetics, in press. 

Seraiah’s first manuscript from her thesis project has been accepted for publication in Chemosphere journal. Congratulations, Seraiah and the team!
**Coe, S., ‡Chakraborty, S., ‡Faheem, M., *Kupradit, K., Bhandari, R.K. (2024). A second hit by PFOS exposure exacerbated developmental defects in medaka embryos with a history of ancestral BPA exposure. Chemosphere, 362: 142796. 

We just got a manuscript entitled "The conflict between regulatory agencies over the 20,000-fold lowering of the tolerable daily intake (TDI) for bisphenol A (BPA) by the European Food Safety Authority (EFSA)" accepted by Environmental Health Perspectives for publication. This landmark paper suggests changes in the existing regulatory guidelines on the tolerable daily intake of BPA. Kudos to Fred for developing this commentary and including me in the group of outstanding scientists in the world.  

Vom saal, F.S., Antoniou, M., Belcher, S., Bergman, A., Bhandari, R.K., and 35 others (2024). The conflict between regulatory agencies over the 20,000-fold lowering of the tolerable daily intake (TDI) for bisphenol A (BPA) by the European Food Safety Authority (EFSA). Environmental Health Perspectives 132 (4): 045001-16. 

We received the funding for the 3rd year of the NIH R01 grant today and are looking forward to exciting research activities for the funding period 2023-2024. Congratulations, team! 👏

November 20, 2023. Monday. 3:30 pm

After three months of hard work, the Bhandari lab has finally started operating. Thanks to everyone in the Bhandari Research Group for outstanding contributions to make this happen. 

Sourav’s second manuscript from the dissertation project has been accepted for publication in Environmental Science and Technology journal. Congratulations, Sourav!
Chakraborty, S., Anand, S., Coe, S., Reh, B., Bhandari, R.K. (2023). The PCOS-NAFLD multi-disease phenotype occurred in medaka fish four generations after the removal of bisphenol A exposure. Environmental Science and Technology 57 (34): 12602–12619.